small transmembrane & glycosylated protein (SMAGP)
Jump to navigation
Jump to search
Function
- may play a role in epithelial cell-cell contacts
Structure
- O-glycosylated
- O-glycan is modified with sialic acid residues
- belongs to the SMAGP family
Compartment
- cell membrane
- cytoplasmic vesicle
- predominantly on lateral parts of the membrane, at cell-cell epithelial junctions
Expression
- detected in breast, endometrium, colon & biliary tract
- detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level)
Pathology
- may play a role in tumor invasiveness & metastasis formation
- detected on cytoplasmic membranes in undifferentiated tumors