Proline-rich protein 7 (synaptic proline-rich membrane protein) (PRR7)

Function

• found in a postsynaptic membrane complex with DLG4 & GRIN1
• interacts with DLG4
• interacts preferentially with the PDZ3 domain of DLG4 & to lesser degree to PDZ2 but not to the PDZ1

Compartment

• membrane
• cell junction, synapse, postsynaptic cell membrane (putative)
• enriched in post-synaptic plasma membrane & postsynaptic densities (PSD)
• accumulates in dendritic spines along with synapse maturation & colocalizes with DLG4 in a punctate pattern (putative)

Alternative splicing

named isoforms=2

More general terms

• proline-rich protein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8075
• UniProt: http://www.uniprot.org/uniprot/Q8TB68.html