fibronectin type III domain-containing protein 5 (fibronectin type III repeat-containing protein 2) (FNDC5 FRCP2)

Function

• cleaved & secreted as the hormone, irisin

Structure

contains 1 fibronectin F3 module

Compartment

• peroxisome membrane
• imported in peroxisomes through the PEX5 receptor pathway (putative)

Alternative splicing

named isoforms=4

Expression

• expressed in skeletal muscle
• induced by PGC1-alpha

More general terms

• glycoprotein
• membrane protein
• secreted protein
• hormone

More specific terms

• irisin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2529
• UniProt: http://www.uniprot.org/uniprot/Q8NAU1.html