Ca+2-binding mitochondrial carrier protein SCaMC-2 (small Ca+2-binding mitochondrial carrier protein 2, mitochondrial ATP-Mg/Pi carrier protein 3, mitochondrial Ca+2-dependent solute carrier protein 3, solute carrier family 25 member 25, SLC25A25, APC3, KIAA1896, MCSC3, SCAMC2, UNQ549/PRO1106)
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Function
- Ca+2-dependent mitochondrial solute carrier
- mitochondrial solute carriers shuttle metabolites, nucleotides, & cofactors through the mitochondrial inner membrane
- may act as ATP-Mg/Pi exchanger that mediates transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
Structure
- belongs to the mitochondrial carrier family
- contains 3 EF-hand domains contains 3 solcar repeats
Compartment
mitochondrial inner membrane
Alternative splicing
named isoforms=6
Expression
- present in various cell lines (at protein level)
- widely expressed
- expressed in fetal & adult liver, skeletal muscle, testis, ovary, hippocampus & caudate nucleus
- isoform 1 is present in all tissues tested
- isoform 2 is restricted to kidney & lung
More general terms
- membrane protein
- Ca+2 binding protein
- mitochondrial protein
- solute carrier family 25 (SLC25, SLC25A)