Ca+2-binding mitochondrial carrier protein SCaMC-1 (small Ca+2-binding mitochondrial carrier protein 1, mitochondrial ATP-Mg/Pi carrier protein 1, mitochondrial Ca(2+)-dependent solute carrier protein 1, solute carrier family 25 member 24, SLC25A24, APC1, MCSC1, SCAMC1)
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Function
- Ca+2-dependent mitochondrial solute carrier
- mitochondrial solute carriers shuttle metabolites, nucleotides, & cofactors through the mitochondrial inner membrane
- may act as a ATP-Mg/Pi exchanger that mediates transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
- KM=0.97 mM for AMP
- KM=0.3 mM for ADP
- KM=0.33 mM for ATP
- KM=0.2 mM for ATP-Mg
- KM=1.64 mM for Pi
- Vmax=337 umol/min/g enzyme with AMP as substrate
- Vmax=345 umol/min/g enzyme with ADP as substrate
- Vmax=320 umol/min/g enzyme with ATP as substrate
- Vmax=365 umol/min/g enzyme with ATP-Mg as substrate
- Vmax=380 umol/min/g enzyme with Pi as substrate
Structure
- belongs to the mitochondrial carrier family
- contains 4 EF-hand domains
- contains 3 solcar repeats
Compartment
mitochondrial inner membrane
Alternative splicing
named isoforms=2
Expression
- present in various cell lines (at protein level)
- expressed in all tissues tested
- expressed in testis > small intestine & pancreas > kidney, spleen, liver, skeletal muscle & heart
More general terms
- membrane protein
- Ca+2 binding protein
- mitochondrial protein
- solute carrier family 25 (SLC25, SLC25A)