phosphatidylinositide phosphatase SAC1 (suppressor of actin mutations 1-like protein, SACM1L, KIAA0851)

Function

• phosphoinositide phosphatase
• hydrolyzes Ptdins3P & Ptdins4P
• low activity towards Ptdins(3,5)P2

Structure

contains 1 SAC domain

Compartment

endoplasmic reticulum membrane

Expression

• detected in heart, brain, lung, liver, kidney, pancreas & testis

More general terms

• phosphomonoesterase
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2290
• OMIM: https://mirror.omim.org/entry/606569
• UniProt: http://www.uniprot.org/uniprot/Q9NTJ5.html