cytochrome b ascorbate-dependent protein 3; cytochrome b561 family member A3; lysosomal cytochrome b; Lcytb (CYB561A3, CYBASC3, LCYTB, PSEC0259)

Function

• ferric-chelate reductase that reduces Fe+3 to Fe+2 before its transport from the endosome to the cytoplasm
• probably uses ascorbate as electron donor (putative)

Cofactor: binds 2 heme groups non-covalently (putative)

Structure

• N-glycosylated (putative)
• contains 1 cytochrome b561 domain

Compartment

late endosome, lysosome membrane

Alternative splicing

named isoforms=2

More general terms

• glycoprotein
• oxidoreductase
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=220002
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:220002
• UniProt: http://www.uniprot.org/uniprot/Q8NBI2.html