CDGSH iron sulfur domain-containing protein 2 (endoplasmic reticulum intermembrane small protein, mitoNEET-related 1 protein, Miner1, CISD2, ERIS, ZCD2)

Function

• may play a role in Ca+2 homeostasis

Cofactor: binds 1 2Fe-2S cluster

Structure

belongs to the CISD protein family

Compartment

• endoplasmic reticulum membrane

Expression

• testis, small intestine, kidney, lung, brain, pancreas & platelets

Pathology

• defects in CISD2 are the cause of Wolfram syndrome 2

More general terms

• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4938
• OMIM: https://mirror.omim.org/entry/604928
• UniProt: http://www.uniprot.org/uniprot/Q8N5K1.html