stearoyl-CoA desaturase 5 (HSCD5, acyl-CoA-desaturase 4, stearoyl-CoA 9-desaturase, SCD5, ACOD4, SCD4)

Function

• fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta 9 position

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ <--> oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O

Cofactor: iron (putative)

Structure

• histidine box domains may contain the active site &/or be involved in metal ion binding (putative)
• belongs to the fatty acid desaturase family

Compartment

• endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• detected in fetal brain > fetal kidney
• detected in adult brain & pancreas > kidney & lung

More general terms

• stearoyl-CoA desaturase
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/608370
• UniProt: http://www.uniprot.org/uniprot/Q86SK9.html