Retinol dehydrogenase 8 (photoreceptor outer segment all-trans retinol dehydrogenase, RDH8, PRRDH)

Function

• retinol dehydrogenase with a clear preference for NADP
• converts all-trans-retinal to all-trans-retinol
• may play a role in regeneration of visual pigment at high light intensity

retinol + NADP+ <--> retinal + NADPH

Structure

• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

membrane (putative)

Expression

• detected in photoreceptor outer segments in the retina (at protein level)

More general terms

• membrane protein
• retinal dehydrogenase

Database

• OMIM: https://mirror.omim.org/entry/608575
• UniProt: http://www.uniprot.org/uniprot/Q9NYR8.html