fatty-acid amide hydrolase 2 (oleamide hydrolase 2, anandamide amidohydrolase 2, amidase domain-containing protein, FAAH2, AMDD)

Function

• degrades bioactive fatty acid amides to their corresponding acids thus terminate their signaling functions, including:
  • oleamide
  • endogenous cannabinoid, anandamide
  • myristic amide
• hydrolyzes monounsaturated substrate anandamide preferentially compared to polyunsaturated substrates
• inhibited by O-aryl carbamates

Structure

• homodimer
• belongs to the amidase family

Compartment

membrane

Expression

• expressed in brain, small intestine, testis > heart, kidney, liver, lung, prostate

More general terms

• hydrolase
• membrane protein

Additional terms

• fatty-acid amide hydrolase

Database

• UniProt: http://www.uniprot.org/uniprot/Q6GMR7.html