globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (Forssman glycolipid synthetase-like protein, GBGT1)

Function

• glycosylation
• catalyzes formation of some glycolipid via addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate
• the glycolipids may serve for adherence of some pathogens
• in contrast to its mouse or canine ortholog, does not mediate formation of Forssman glycolipid (Forssman antigen), which does not exist in human

Cofactor: Mn+2 Manganese

Structure

• conserved DXD motif is involved in cofactor binding
• Mn+2 interacts with the beta-phosphate group of UDP & may have a role in catalysis
• belongs to the glycosyltransferase 6 family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in placenta, ovary, peripheral blood leukocytes > liver, thymus, testis

More general terms

• membrane protein
• glycoprotein
• glycosyltransferase

Database

• OMIM: https://mirror.omim.org/entry/606074
• UniProt: http://www.uniprot.org/uniprot/Q8N5D6.html