1-acyl-sn-glycerol-3-phosphate acyltransferase zeta (1-AGP acyltransferase 6, 1-AGPAT 6, lysophosphatidic acid acyltransferase zeta, LPAAT-zeta, AGPAT6)

Function

• de novo phospholipid biosynthesis, 2nd step
• converts lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
• HXXXXD motif is essential for acyltransferase activity, binding site for phosphate moiety glycerol-3-phosphate (putative)

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate  <-->
              CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate
• belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

membrane

Expression

• expressed in skeletal muscle, heart, testis > lung

More general terms

• 1-acyl-sn-glycerol-3-phosphate acyltransferase
• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/608143
• UniProt: http://www.uniprot.org/uniprot/Q86UL3.html