chitobiosyldiphosphodolichol beta-mannosyltransferase; asparagine-linked glycosylation protein 1 homolog; beta-1,4-mannosyltransferase; GDP-man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; mannosyltransferase-1; MT-1; hmat-1 (ALG1, HMAT1, HMT1, PSEC0061, UNQ861/PRO1870)

Function

• participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation
• assembly of dolichol-pyrophosphate-GlcNAc(2)-Man(5) on the cytoplasmic surface of the ER
• glycosylation

Structure

• belongs to the glycosyltransferase group 1 family glycosyltransferase 33 subfamily

Compartment

• endoplasmic reticulum membrane
• single-pass type 2 membrane protein

Pathology

• defects in ALG1 are the cause of congenital disorder of glycosylation type 1K (CDG-1k)

More general terms

• glycosyltransferase
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56052
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56052
• OMIM: https://mirror.omim.org/entry/605907
• OMIM: https://mirror.omim.org/entry/608540
• UniProt: http://www.uniprot.org/uniprot/Q9BT22.html