Nesprin-3 (SYNE3, C14orf49)

Function

• role in the maintenance of nuclear organization & structural integrity
• probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system
• interacts with actin-binding domain of PLEC1/plectin

Structure

• belongs to the nesprin family
• contains 1 KASH domain
• contains 2 spectrin repeats

Compartment

• nucleus outer membrane
• located at the rough endoplasmic reticulum in some cells

Alternative splicing

named isoforms=3

More general terms

• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZMZ3.html