CUB & zona pellucida-like domain-containing protein 1 (transmembrane protein UO-44, CUZD1)

Function

• role in uterus during late pregnancy &/or in trypsin activation in pancreatic acinar cells

Structure

• contains 2 CUB domains
• contains 1 ZP domain

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

detected in pancreas & epithelium of ovary

Pathology

• expressed at higher levels in ovarian tumors than in normal tissue
• CUZD1 antiserum inhibits cell attachment & proliferation of ovarian cancer cells

More general terms

• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UP6.html