amnionless protein (AMN)

Function

• necessary for efficient absorption of vitamin B12
• may direct production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling in the underlying visceral endoderm
• interacts with CUBN/cubilin

Structure

• contains 1 VWFC domain

Compartment

membrane Alternative promoter:

• named isoforms=1
• at least 5 isoforms, 1, 2, 3, 4 & 5

Expression

• long isoforms are highly expressed in small intestine, colon & kidney (renal proximal tubule epithelial cells)
• shorter isoforms are detected at lower levels in testis, thymus, peripheral blood leukocytes

Pathology

• defects in AMN are a cause of recessive hereditary megaloblastic anemia 1

More general terms

• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/261100
• OMIM: https://mirror.omim.org/entry/605799
• UniProt: http://www.uniprot.org/uniprot/Q9BXJ7.html