nuclear pore membrane glycoprotein 210 (POM210, nuclear pore protein gp210, NUP210, KIAA0906, PSEC0245)

Function

• nucleoporin
• phosphorylated at Ser-1881 in mitosis
• not phosphorylated in interphase

Structure

• forms dimers & possibly higher-order oligomers
• N-glycosylated
• contains high-mannose type oligosaccharides

Compartment

• nuclear pore complex, endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitous expression
• expressed in lung, liver, pancreas, testis, ovary > brain, kidney, spleen > heart, skeletal muscle

Pathology

• recognized by antinuclear autoantibodies in primary biliary cirrhosis
• knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures & nuclear pore complex to cluster, induces cell death & chromatin disruptions

More general terms

• glycoprotein
• membrane protein
• phosphoprotein

Component of

• nuclear pore complex (NPC)

Database

• OMIM: https://mirror.omim.org/entry/607703
• UniProt: http://www.uniprot.org/uniprot/Q8TEM1.html