CUB & SUSHI domain-containing protein 1; CUB & SUSHI multiple domains protein 1 (CSMD1, KIAA1890, UNQ5952/PRO19863)
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Function
- may suppress squamous cell carcinomas
Structure
- belongs to the CSMD family
- contains 14 CUB domains
- contains 28 Sushi domains
Compartment
- membrane; single-pass type 2 membrane protein (putative)
Alternative splicing
named isoforms=4
Expression
- weakly expressed in most tissues, except in brain
- expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus & fetal brain
Pathology
- defects in CSMD1 may be a associated with oral & oropharyngeal squamous cell carcinomas
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q96PZ7.html
- ↑ Toomes C The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis. Genes Chromosomes Cancer. 2003 Jun;37(2):132-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12696061
- ↑ Scholnick SB and Richter TM. The role of CSMD1 in head and neck carcinogenesis. Genes Chromosomes Cancer. 2003 Nov;38(3):281-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14506705