Na+/H+ exchanger NHE2 (solute carrier family 9 member 2, SLC9A2)

Function

• role in pH regulation
• elimination of acids generated by active metabolism or adverse environmental conditions
• major proton extruding system
• proton elimination driven by the inward Na+ chemical gradient
• role in colonic Na+ absorption
• phosphorylated (putative)

Structure

• belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Compartment

membrane

Expression

• expressed in skeletal muscle, colon & kidney > testis, prostate, ovary, & small intestine

More general terms

• transmembrane 10 protein
• solute carrier family 9 (SLC9, SLC9A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6549
• OMIM: https://mirror.omim.org/entry/600530
• UniProt: http://www.uniprot.org/uniprot/Q9UBY0.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6549