soluble Ca+2-activated nucleotidase 1; SCAN-1; Apyrase homolog; MAPK-activating protein PM09; NF-kappa-B-activating protein 107 (CANT1, SHAPY)

Function

• Ca+2-dependent nucleotidase, preference for UDP > GDP > UTP > GTP > ADP > ATP
  • does not hydrolyze AMP, GMP

Cofactor: Ca+2

Kinetic parameters:

• Optimum pH is 6.8

Structure

• monomer
• N-glycosylated
• belongs to the apyrase family

Compartment

cell membrane, secreted

Alternative splicing

named isoforms=2

Expression

widely expressed

Pathology

• defects in CANT1 are the cause of Desbuquois dysplasia

Notes

• not inhibited by azide

More general terms

• nucleotidase
• membrane protein
• glycoprotein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=124583
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:124583
• OMIM: https://mirror.omim.org/entry/251450
• OMIM: https://mirror.omim.org/entry/613165
• UniProt: http://www.uniprot.org/uniprot/Q8WVQ1.html