protein tyrosine phosphatase type IVA, member 2; protein tyrosine phosphatase 4a2; protein-tyrosine phosphatase of regenerating liver-2; PRL-2; HU-PP-1; OV-1 (PTP4A2, PRL2, PTPCAAX2, BM-008)

Function

• stimulates progression from G1 into S phase during mitosis
• promotes tumor growth
• inhibits geranylgeranyl transferase-2 via inhibiting interaction of RABGGTA with RABGGTB

Inhibition:

• inhibited by sodium orthovanadate, pentamidine

Structure

farnesylated

Compartment

plasma membrane, early endosome, cytoplasm

Expression

• ubiquitously expressed
• highest levels in skeletal muscle, heart, thymus

Pathology

overexpressed in prostate cancer

More general terms

• protein tyrosine phosphatase type IVA
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/601584
• UniProt: http://www.uniprot.org/uniprot/Q12974.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8073