5,6-dihydroxyindole-2-carboxylic acid oxidase; DHICA oxidase; tyrosinase-related protein 1; TYRP1, catalase B; glycoprotein-75; gp75; brown [b] locus protein homolog; CAS2 protein; melanoma antigen gp75; monophenol monooxygenase homolog (TYRP1, CAS2, TYRP, TYRRP)
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Function
- oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid
- may regulate or influence the type of melanin synthesized
- pigment biosynthesis; melanin biosynthesis
Cofactor: binds 2 copper ions per subunit (putative)
Structure
belongs to the tyrosinase family
Compartment
melanosome membrane
Expression
pigment cells
Pathology
- defects in TYRP1 are the cause of
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P17643.html
- ↑ Mutations of the TYRP1 gene Note: Retina International's Scientific newsletter http://www.retina-international.com/sci-news/trp1mut.htm
- ↑ Albinism database (ADB); Note: TYRP1 mutations http://albinismdb.med.umn.edu/oca3mut.html
Database
- UniProt: http://www.uniprot.org/uniprot/P17643.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7306
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7306
- OMIM: https://mirror.omim.org/entry/115501
- OMIM: https://mirror.omim.org/entry/203290
- OMIM: https://mirror.omim.org/entry/278400