flavoprotein monooxygenase 4; dimethylaniline oxidase 4; dimethylaniline monooxygenase [N-oxide forming] 4 (FMO4)

Function

• role in oxidative metabolism of a variety of xenobiotics such as drugs & pesticides

N,N-dimethylaniline + NADPH + O2
         <-->
N,N- dimethylaniline N-oxide + NADP+ + H2O

Cofactor: FAD

Structure

belongs to the FMO family

Compartment

• microsome membrane
• endoplasmic reticulum membrane

Expression

liver

Polymorphism

• polymorphism in FMO4 associated with fish-odor syndrome

More general terms

• flavoprotein mixed function oxidase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P31512.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2329
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2329
• OMIM: https://mirror.omim.org/entry/136131