flavoprotein monooxygenase 1; dimethylaniline oxidase 1; dimethylaniline monooxygenase [N-oxide forming] (FMO1)

Function

• role in oxidative metabolism of xenobiotics including drugs & pesticides
• form I catalyzes the N-oxygenation of secondary & tertiary amines

N,N-dimethylaniline + NADPH + O2
       <-->
N,N-dimethylaniline N-oxide + NADP+ + H2O

Cofactor: FAD

Structure

belongs to the FMO family

Compartment

• microsome membrane
• endoplasmic reticulum membrane

Expression

• expressed fetal liver, adult kidney > intestine

More general terms

• flavoprotein mixed function oxidase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01740.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2326
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2326
• OMIM: https://mirror.omim.org/entry/136130