semaphorin-6C; semaphorin-Y; sema Y (SEMA6C KIAA1869 SEMAY)

Function

• growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro
• may be a stop signal for the DRG neurons in their target areas, & possibly also for other neurons
• may alsoplay role in maintenance & remodeling of neuronal connections

Structure

• belongs to the semaphorin family
• contains 1 PSI domain
• contains 1 sema domain

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=3

Expression

• in adult tissues, expressed only in skeletal muscle

More general terms

• membrane protein
• glycoprotein
• semaphorin or semaphorin/collapsin family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10500
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10500
• OMIM: https://mirror.omim.org/entry/609294
• UniProt: http://www.uniprot.org/uniprot/Q9H3T2.html