translocon-associated protein subunit beta; TRAP-beta; signal sequence receptor subunit beta; SSR-beta (SSR2, TRAPB, HSD25)

Function

• subunit of signal sequence receptor whose function is to bind Ca+2 to the ER membrane & thus regulate retention of ER resident proteins
• interacts with TMEM173/STING

Structure

belongs to the TRAP-beta family

Compartment

endoplasmic reticulum membrane

More general terms

• glycoprotein
• membrane protein
• protein subunit

Component of

• endoplasmic reticulum signal sequence receptor (SSR, translocon-associated protein, TRAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6746
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6746
• OMIM: https://mirror.omim.org/entry/600867
• UniProt: http://www.uniprot.org/uniprot/P43308.html