iodothyronine deiodinase type 1 (DIO1)

Function

• responsible for the deiodination of T4 into T3 & of T3 into T2 (3,3'-diiodothyronine)
• plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues including liver & kidney

3,5,3'-triiodo-L-thyronine + iodide + A + H+
        <-->
L-thyroxine + AH(2)

Structure

belongs to the iodothyronine deiodinase family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=9

More general terms

• iodothyronine deiodinase
• membrane protein

Additional terms

• thyrosine/iodothyronine [T4] deiodinase, iodide peroxidase or T3 synthase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1733
• OMIM: https://mirror.omim.org/entry/147892
• UniProt: http://www.uniprot.org/uniprot/P49895.html