aldehyde dehydrogenase 3 family, member A2 (aldehyde dehydrogenase 10, microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10 FALDH)

Function

• catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids
• active on a variety of saturated & unsaturated aliphatic aldehydes between 6 & 24 carbons in length

an aldehyde + NAD+ + H2O <--> an acid + NADH

Structure

belongs to the aldehyde dehydrogenase family

Compartment

• endoplasmic reticulum membrane, cytoplasmic side

Alternative splicing

named isoforms=2

Pathology

• defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome

Laboratory

• ALDH3A2 gene mutation

More general terms

• aldehyde dehydrogenase
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:224
• OMIM: https://mirror.omim.org/entry/270200
• UniProt: http://www.uniprot.org/uniprot/P51648.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=224