carbonic anhydrase-12 (tumor antigen HOM-RCC-3.1.3, CA12)

Function

• reversible hydration of carbon dioxide
• inhibited by acetazolamide

H2CO3 <--> CO2 + H2O

Cofactor: Zn+2 (putative)

Structure

belongs to the alpha-carbonic anhydrase family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in colon, kidney, prostate, intestine & activated lymphocytes
• moderately expressed in pancreas, ovary & testis

Pathology

• expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue

More general terms

• carbonic anhydrase (dehydratase)
• glycoprotein
• membrane protein
• metalloprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:771
• OMIM: https://mirror.omim.org/entry/603263
• UniProt: http://www.uniprot.org/uniprot/O43570.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=771