Na+-coupled monocarboxylate transporter 2 (electroneutral Na+ monocarboxylate cotransporter, low-affinity Na+-lactate cotransporter, solute carrier family 5 member 12, SLC5A12, SMCT2)

Function

• acts as an electroneutral & low-affinity Na+ dependent Na+ coupled solute transporter
• catalyzes transport across the plasma membrane of many monocarboxylates including lactate, pyruvate, nicotinate, propionate, butyrate & beta-D-hydroxybutyrate
• may be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney & the small intestine
• may play a role in monocarboxylates transport in the retina (putative)
• mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate (putative)

Structure

• belongs to the Na+:solute symporter (SSF) (TC 2.A.21) family

Compartment

• apical cell membrane
• detected at the brush border membrane of the kidney
• colocalizes with viementin in Mueller cells (putative)

Alternative splicing

named isoforms=2

More general terms

• glycoprotein
• transmembrane 13 protein
• solute carrier family 5 (SLC5, SLC5A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1599
• UniProt: http://www.uniprot.org/uniprot/Q1EHB4.html