Shadow of prion protein (Protein shadoo) (SPRN SHO)

Function

• prion-like protein that has PrP(C)-like neuroprotective activity
• may act as a modulator for the biological actions of normal & abnormal PrP (putative)
• N-glycosylated (putative)

Structure

belongs to the SPRN family

Compartment

-cell membrane; lipid-anchor, GPI-anchor

Expression

• mainly expressed in brain
• in brain, it is expressed in hippocampus

Notes

'Shadoo' means 'shadow' in Japanese

More general terms

• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5035
• UniProt: http://www.uniprot.org/uniprot/Q5BIV9.html