von Willebrand factor C & EGF domain-containing protein (HBV X protein up-regulated gene 11 protein, HBxAg up-regulated gene 11 protein, VWCE, URG11)

Function

• may be a regulatory element in the beta-catenin signaling pathway & a target for chemoprevention of hepatocellular carcinoma

Structure

• contains 4 EGF-like domains
• contains 6 VWFC domains

Compartment

secreted (putative), cytoplasm ?

Alternative splicing

named isoforms=2

Expression

• expressed in liver
• induced by HBxAg

More general terms

• glycoprotein
• secreted protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2200
• UniProt: http://www.uniprot.org/uniprot/Q96DN2.html