lipid phosphate phosphatase-related protein type 4 (plasticity-related gene 1 protein, PRG-1, brain-specific phosphatidic acid phosphatase-like protein 1, LPPR4, KIAA0455, PRG1)

Function

• hydrolyzes lysophosphatidic acid
• facilitates axonal outgrowth during development & regenerative sprouting
• in the outgrowing axons acts as an ecto-enzyme & attenuates phospholipid-induced axon collapse in neurons & facilitates outgrowth in the hippocampus

3-sn-phosphatidate + H2O <--> a 1,2-diacyl-sn-glycerol + phosphate

Structure

• belongs to the PA-phosphatase related phosphoesterase family

Compartment

membrane (putative)

Alternative splicing

named isoforms=2

Expression

specifically expressed in neurons

More general terms

• phosphomonoesterase
• glycoprotein
• lipid phosphate phosphatase-related protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9890
• OMIM: https://mirror.omim.org/entry/607813
• UniProt: http://www.uniprot.org/uniprot/Q7Z2D5.html