C3 & PZP-like alpha-2-macroglobulin domain-containing protein 8 (CPAMD8, KIAA1283)

Function

• interacts with heparin
• appears to be proteolytically cleaved into two chains of about 70 & 130 kDa

Structure

• belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family
• contains 1 Kazal-like domain

Compartment

• secreted (putative)
• membrane, plasma membrane-associated

Alternative splicing

named isoforms=2

Expression

• expressed in the kidney, brain & testis > heart, liver & small intestine
• up-regulated by IL1-beta & IL6

More general terms

• secreted protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2715
• OMIM: https://mirror.omim.org/entry/608841
• UniProt: http://www.uniprot.org/uniprot/Q8IZJ3.html