glycosyltransferase 25 family member 1; procollagen galactosyltransferase 1; collagen beta(1-O)galactosyltransferase 1; hydroxylysine galactosyltransferase 1 (COLGALT1, GLT25D1, PSEC0241)

Function

• beta-galactosyltransferase activity
• transfers beta-galactose to hydroxylysine residues of collagen
• has no glucosyltransferase activity

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen]

Kinetic parameters:

• KM=18.7 uM for UDP-galactose

Structure

• N-glycosylated
• belongs to the glycosyltransferase 25 family

Compartment

• endoplasmic reticulum lumen (putative)
• colocalized with PLOD3 & mannose binding lectin

Expression

• ubiquitous
• higher levels in placenta, heart, lung & spleen

More general terms

• galactosyltransferase
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79709
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79709
• UniProt: http://www.uniprot.org/uniprot/Q8NBJ5.html