glutaminyl-peptide cyclotransferase (QC, glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, QPCT)

Function

• biosynthesis of pyroglutamyl peptides
• has bias against acidic & tryptophan residues adjacent to N-terminal glutaminyl residue
• indifferent to chain length after the 2nd residue

L-glutaminyl-peptide <--> 5-oxoprolyl-peptide + NH3

More general terms

• acyltransferase
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607065
• UniProt: http://www.uniprot.org/uniprot/Q16769.html