glycerophosphodiester phosphodiesterase 1 (membrane interacting protein of RGS16, RGS16-interacting membrane protein, GDE1, MIR16)

Function

• glycerophosphoinositol phosphodiesterase activity
• little or no activity towards glycerophosphocholine
• GDE1 activity can be modulated by G-protein signaling pathways
• interacts with RGS16
• interacts with PRAF2

1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O
<-->
myo-inositol + sn-glycerol 3-phosphate

Structure

• N-glycosylated
• belongs to the glycerophosphoryl diester phosphodiesterase family
• contains 1 GDPD domain

Compartment

• cytoplasm, membrane
• perinuclear vesicles & cell membrane

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• phosphodiesterase
• glycoprotein
• transmembrane 2 protein

Database

• OMIM: https://mirror.omim.org/entry/605943
• UniProt: http://www.uniprot.org/uniprot/Q9NZC3.html