large neutral amino acids transporter small subunit 4 (L-type amino L-acid transporter 4, solute carrier family 43 member 2, SLC43A2, LAT4, PP7664)

Function

• Na+, Cl-, pH-independent high affinity transport of large neutral amino acids

Structure

• glycosylated (putative)
• belongs to the SLC43A transporter (TC 2.A.1.44) family

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• detected in several tissues
• higher expression in placenta, kidney & peripheral blood leukocytes
• in kidney, detected in epithelial cells of the distal tubule & collecting duct
• in the intestine, expressed mainly in crypt cells of the intestinal microvilli & epithelial cells in the base of the villus

More general terms

• amino acid transport protein
• glycoprotein
• phosphoprotein
• solute carrier family 43 (SLC43, SLC43A)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N370.html