latent-transforming growth factor beta-binding protein 4 (LTBP-4, LTBP4)

Function

• may be involved in assembly, secretion & targeting of TGFB1 to sites at which it is stored &/or activated
• may play role in controlling & directing the activity of TGFB1
• may have a structural role in the extra cellular matrix (ECM)
• forms part of the large latent TGF-beta precursor complex; removal is essential for activation of complex
• interacts with LTBP1 & TGFB1
• binds to FBN1
• contains hydroxylated asparagine residues (putative)

Structure

• belongs to the LTBP family
• contains 16 EGF-like domains
• contains 4 TGFBP (TGF-beta binding protein) repeats

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=4

Expression

• expressed in heart, skeletal muscle, pancreas, uterus, & small intestine > placenta & lung > fetal brain, liver, heart, spleen & thymus

More general terms

• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604710
• UniProt: http://www.uniprot.org/uniprot/Q8N2S1.html