Izumo sperm-egg fusion protein 1 (sperm-specific protein izumo) (IZUMO1)

Function

• role in the fertilization process
• role in fusion of sperm with egg

Structure

• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• sperm-specific (at protein level)
• detectable on sperm surface only after the acrosome reaction Misc: Izumo is the name of a Japanese shrine to marriage

More general terms

• testis-specific protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IYV9.html