inactive serine protease RAMP; regeneration-associated muscle protease homolog (RAMP, PAMR1)

Function

• role in regeneration of skeletal muscle (putative)

Structure

• belongs to the peptidase S1 family
• although related to peptidase S1 family, conserved active Ser residue in position 665 is replaced by Thr, thus thought to have no protease activity
• contains 1 CUB domain
• contains 1 EGF-like domain
• contains 1 peptidase S1 domain
• contains 2 Sushi domains (CCP/SCR domains)

Compartment

secreted

Alternative splicing

named isoforms=2

Pathology

• strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line

More general terms

• glycoprotein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UXH9.html