Na+-coupled neutral amino acid transporter 4 (amino acid transporter A3, system A amino acid transporter 3, system N amino acid transporter 3, solute carrier family 38 member 4, SLC38A4, ATA3, NAT3, SNAT4)
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Function
- Na+-dependent amino acid transporte
- mediates electrogenic symport of neutral amino acids & Na+
- broad specificity, with a preference for Ala > His, Cys, Asn, Ser, Gly, Val, Thr, Gln & Met
- may mediate Na+-independent transport of cationic amino acids, Arg & Lys
- amino acid uptake is pH-dependent, pH optimum 7.5-8.5
Structure
- belongs to the amino acid/polyamine transporter 2 family
Compartment
Expression
- expressed in embryonic & adult liver > adult muscle, kidney, pancreas
- expressed in placenta syncytiotrophoblasts throughout gestation
- expressed in fetal blood vessels
More general terms
- transmembrane 11 protein
- amino acid transport protein
- glycoprotein
- solute carrier family 38 (SLC38, SLC38A)