sulfatase-modifying factor 2 (C-alpha-formyglycine-generating enzyme 2, SUMF2)

Function

• unlike SUMF1
  • lacks formyl-glycine generating activity
  • unable to convert newly synthesized inactive sulfatases to their active form by modifying an active site Cys to 3-oxoalanine
• overexpression of SUMF2 inhibits activation of sulfatases by SUMF1

Compartment

endoplasmic reticulum lumen

Alternative splicing

named isoforms=4

Expression

• detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• Ca+2 binding protein
• glycoprotein

Additional terms

• sulfatase-modifying factor 1; C-alpha-formyglycine-generating enzyme 1 (SUMF1, FGE, PSEC0152, UNQ3037/PRO9852)

Database

• OMIM: https://mirror.omim.org/entry/607940
• UniProt: http://www.uniprot.org/uniprot/Q8NBJ7.html