R-spondin-4 (roof plate-specific spondin-4, hRspo4, RSPO4, C20orf182)

Function

• activator of the beta-catenin signaling cascade
• TCF-dependent gene activation
• role in Wnt/beta-catenin-dependent pathway
  • via a direct interaction with Wnt proteins
• role in Wnt-independent beta catenin pathway
• binds heparin
• FU repeat required for activation & stabilization of beta-catenin
• Tyr-112 may be phosphorylated, but is probably extracellular
• upon injection into mice, induces rapid onset of crypt cell proliferation involving beta-catenin stabilization
• efficacy in a model of chemotherapy-induced intestinal mucositis

Compartment

secreted

Alternative splicing

named isoforms=2

More general terms

• R-spondin (roof plate-specific spondin)
• glycoprotein

Additional terms

• Wnt-1 signalling

Database

• UniProt: http://www.uniprot.org/uniprot/Q2I0M5.html