tectonic-1 (TECT1, TCTN1)

Function

• regulator of Hedgehog
• required for both activation & inhibition of the Hedgehog pathway in the patterning of the neural tube
• during neural tube development, required for formation of the most ventral cell types & for full Hedgehog pathway activation
• modulates Hedgehog signal transduction downstream of SMO & RAB23 (putative)

Compartment

secreted

Alternative splicing

named isoforms=6

More general terms

• tectonic protein
• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q2MV58.html