Eenamelin (ENAM)

Function

• role in the mineralization & structural organization of enamel
• role in extension of enamel during the secretory stage of dental enamel formation

Compartment

• secreted, extracellular space, extracellular matrix

Expression

• expressed in tooth particularly in odontoblast, ameloblast & cementoblast

Pathology

• defects in ENAM are the cause of
  • amelogenesis imperfecta hypoplastic type 1B
  • amelogenesis imperfecta type 1C

More general terms

• secreted protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10117
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10117
• OMIM: https://mirror.omim.org/entry/104500
• OMIM: https://mirror.omim.org/entry/204650
• OMIM: https://mirror.omim.org/entry/606585
• UniProt: http://www.uniprot.org/uniprot/Q9NRM1.html