gamma-glutamyl hydrolase; conjugase; GH; gamma-Glu-X carboxypeptidase (GGH)

Function

• hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates
• progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) & free glutamate
• may play an important role in the bioavailability of dietary pteroylpolyglutamates & in the metabolism of pteroylpolyglutamates & antifolates
• hydrolysis of a gamma-glutamyl bond
• homodimer (probable)

Structure

• belongs to the peptidase C26 family
• contains 1 gamma-glutamyl hydrolase domain

Compartment

• secreted, extracellular space
• lysosome, melanosome
• intracellular location is primarily the lysosome; however, most of enzyme activity is secreted
• identified by mass spectrometry in melanosome fractions from stage 1 to stage 4

More general terms

• carboxypeptidase
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8836
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8836
• OMIM: https://mirror.omim.org/entry/601509
• UniProt: http://www.uniprot.org/uniprot/Q92820.html