lysosomal Pro-X carboxypeptidase; angiotensinase C; lysosomal carboxypeptidase C; proline carboxypeptidase; prolylcarboxypeptidase; PRCP (PRCP, PCP)

Function

• cleaves C-terminal amino acids linked to proline in peptides such as angiotensin-2, angiotensin-3 & des-Arg9-bradykinin
• cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH
• cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid

Structure

• homodimer
• belongs to the peptidase S28 family

Compartment

lysosome

Expression

• highest expression in placenta, lung & liver
• also expressed in heart, brain, pancreas & kidney

More general terms

• carboxypeptidase
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5547
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5547
• OMIM: https://mirror.omim.org/entry/176785
• UniProt: http://www.uniprot.org/uniprot/P42785.html