receptor-type tyrosine-protein phosphatase T; R-PTP-T; RPTP-rho (PTPRT, R-PTP-T, RPTP-rho, KIAA0283)

Function

• may be involved in both signal transduction & cellular adhesion in the CNS
• receptor tyrosine phosphatase

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 2B subfamily
• contains 4 fibronectin F3 modules
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 MAM domain
• contains 2 tyrosine-protein phosphatase domains

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in colon, lung, heart & testis, fetal & adult brain
• not detected in muscle & peripheral blood leukocytes

More general terms

• cell surface receptor
• tyrosine phosphatase (protein tyrosine phosphatate, PTP)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1112
• UniProt: http://www.uniprot.org/uniprot/O14522.html